Proposed 1st WHO International Standards for Cancer Genomes
NIBSC is currently preparing the proposed WHO 1st International Standards for Cancer Genomes; three genomic DNAs of two cancer and one wildtype genomes.
These materials are intended as both calibrants in the quantification of (predicted) clinically-relevant variants PIK3CA p.E454K, TP53 p.R306*, NRAS p.G12C, PTEN p.K267fs*9, and MAP2K1/MEK1 p.D67N, and as reference materials to validate assay performance with multiple other genome-wide variants in these pan-cancer materials.